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A masked man. A single glove. And now — DNA that could unmask a kidnapper. Three weeks after 84-year-old Nancy Guthrie vanished from her Tucson home, investigators are turning to cutting-edge genetic genealogy in a high-stakes effort to identify a suspect. DNA recovered near the scene didn’t match anything in the FBI’s CODIS database. But authorities believe they may have found genetic material that belongs to the person who took her. If that’s true, experts say it’s only a matter of time. The same investigative technique helped catch the Golden State Killer and Bryan Kohberger. Now it could expose whoever was caught on camera outside Guthrie’s home — armed, masked, wearing a distinctive Ozark Trail backpack. More than 19,000 tips have poured in. A reward exceeding $200,000 is on the table. Federal, state, and local agencies are combing through partial DNA, security footage, credit card trails, even backpack sales across Arizona. And the sheriff has a warning: if you’re responsible, you should be worried. Because this case isn’t cold. And the science may be closing in.

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Arizona authorities turn to genetic genealogy in ongoing search for Nancy Guthrie

Nancy Guthrie, 84, was reported missing from her home in the Tucson, Arizona, area on Feb. 1. She was last seen the night before, when family dropped her off at home.

Federal and local authorities will use genetic genealogy to analyze DNA found at Nancy Guthrie’s home as the ongoing investigation into her possible abduction stretches into its third week.

The 84-year-old mother of “TODAY” co-host Savannah Guthrie was reported missing around noon on Feb. 1 after she did not show up to a friend’s house to attend virtual church services. Guthrie was last seen the previous night at around 9:45, after dinner at her daughter Annie’s house.

A combination of images captured by Nancy Guthrie's home security camera

Authorities believe that Guthrie was possibly taken from her home. They have not publicly identified a suspect or person of interest. All members of the Guthrie family have been cleared as potential suspects in the case, which involves local, state and federal law enforcement agencies.

In an update this week, authorities said DNA recovered from a glove found about 2 miles from Guthrie’s home did not match any samples in the FBI’s DNA database, called CODIS, nor did it match DNA found at Guthrie’s property, authorities said Tuesday. The Combined DNA Index System has 19 million offender DNA profiles and more than 1 million forensic profiles, according to the FBI. But a match would not necessarily break the case.

The glove appeared to match the gloves worn by a person seen in security video from outside Guthrie’s home, authorities have said.

Pima County Sheriff Chris Nanos on Tuesday told NBC News that investigators are analyzing some partial DNA that was found at Guthrie’s home. Investigators are also exploring “investigative genetic genealogy options” to identify possible DNA matches, the department said.

“We believe that we may have some DNA there that may be our suspect, but we won’t know that until that DNA is separated, sorted out, maybe admitted to CODIS, maybe through genetic genealogy,” Nanos said.

Investigators are now turning to genetic genealogy, which has previously successfully identified other high-profile criminals like the Golden State Killer and University of Idaho murderer Bryan Kohberger.

“If I was the kidnapper, I would be extremely concerned right now, because using investigative genetic genealogy, he will be identified,” DNA expert CeCe Moore told “TODAY” Thursday.

Authorities, however, are not allowed to use well-known genealogy sites such as Ancestry.com or 23andMe, and will have to rely on publicly available DNA databases to test the DNA. Moore noted that the process may take awhile.

“If they have deep roots in the United States, it could be minutes, it could be a few hours,” Moore said. “But if it’s somebody who doesn’t have connections to the U.S. in their tree in more recent generations, then it could take much longer.”

Last week, the FBI released security camera images and videos of an armed and masked man outside Guthrie’s home on the morning of her disappearance. The FBI has since described that suspect as a 5’9” to 5’10” male carrying a unique gun holster and an Ozark Trail backpack from Walmart. He also may have been wearing a ring.

Nanos noted that identifying the suspect’s backpack could be a critical clue in the investigation.

“We’re working with our Walmart managers all across the state to try to find out how many sales there were of that backpack in the last 20, 30 days, the last 60 days,” Nanos said. “And can we do something with that? Can we break it — maybe we’ll find a credit card or a bank card? Maybe we’ll find a video of the guy walking in.”

The FBI currently has a $100,000 reward for information leading to the location of Guthrie or an arrest for anyone involved in her disappearance. As of Thursday morning, the FBI said it has received more than 19,000 tips related to the case since Feb. 1.

An additional $102,500 reward is being offered through Tucson Crime Stoppers, known locally as 88-CRIME.

There’s no evidence that Guthrie was taken over the U.S.-Mexico border, two officials briefed on the case said.

The Pima County Sheriff’s Department and, later, the FBI have been in touch with officials on both sides of the border to share information in the case, officials said, noting that such outreach is standard in missing-person cases like this one.

The Sonora State Attorney General’s Office said Thursday that it has not received a “formal request for collaboration, assistance, or information exchange from U.S. authorities or Mexican federal agencies in connection with this case.” The statement added that should “an official request be received through the appropriate institutional channels, it will be addressed with full cooperation and within the scope of its legal authority and existing cooperation mechanisms.”

A Tucson attorney confirmed to NBC affiliate News12 that his client, 37-year-old Luke Daley, was briefly detained Friday night during a search of his home but was not arrested. Daley has no link whatsoever to Nancy Guthrie and has no information related to her kidnapping, his attorney said.

A combination of images captured by Nancy Guthrie's home security camera

“Like the entire Tucson community, both Mr. Daley and his mother are hopeful that Nancy will be returned to her family unharmed,” attorney Chris Scileppi said in a statement.

As authorities continue to comb through thousands of tips and leads, Nanos stressed that the case is far from cold.

“As long as we have the ability to chase a lead, it’s not cold,” Nanos said. “We’re not going to give up. We’re going to find Nancy, and we’re going to find out who did this.”

In Hainesport Township, families are waking up to dead geese and ducks scattered across sidewalks, porches, and even school bus stops amid a suspected bird flu outbreak spreading through South Jersey. One mother says her son watched a goose “fall right out of the sky” into their backyard — a moment she calls traumatizing. State officials report more than 1,100 sick or dead birds statewide in just days, and parks in Gloucester County have already shut down. But in Hainesport, neighbors say they’ve been told disposal is their responsibility — armed with gloves, masks, and trash bags. One resident claims he bagged 18 dead geese in a single day… with dozens more still in his yard.
In Hainesport Township, families are waking up to dead geese and ducks scattered across sidewalks, porches, and even school bus stops amid a suspected bird flu outbreak spreading through South Jersey. One mother says her son watched a goose “fall right out of the sky” into their backyard — a moment she calls traumatizing. State officials report more than 1,100 sick or dead birds statewide in just days, and parks in Gloucester County have already shut down. But in Hainesport, neighbors say they’ve been told disposal is their responsibility — armed with gloves, masks, and trash bags. One resident claims he bagged 18 dead geese in a single day… with dozens more still in his yard.

Traumatized Hainesport Twp. residents forced to dispose dead birds amid suspected outbreak An error has occurred. Please contact…

After analyzing nearly 500 feline tumors across multiple countries, researchers found the same cancer-linked mutations seen in human blood, lung, bone, skin and even breast cancers. One mutation — FBXW7 — appears far more often in cats than in people, but when it shows up in humans, outcomes are worse. Here’s the twist: common chemotherapy drugs like vincristine may slow those tumors in cats — potentially offering a faster, real-world testing ground for treatments that could later help human patients.
After analyzing nearly 500 feline tumors across multiple countries, researchers found the same cancer-linked mutations seen in human blood, lung, bone, skin and even breast cancers. One mutation — FBXW7 — appears far more often in cats than in people, but when it shows up in humans, outcomes are worse. Here’s the twist: common chemotherapy drugs like vincristine may slow those tumors in cats — potentially offering a faster, real-world testing ground for treatments that could later help human patients.

Cats give genetic clues to better cancer treatments Similarities between pet and human tumours suggest new ideas for…

Andrew Mountbatten-Windsor — brother of Charles III and once one of the most privileged men in Britain — was arrested this week in a stunning twist tied to the fallout from the Jeffrey Epstein files. For the first time in nearly 400 years, a British royal has been taken in for questioning. The message from the Palace? “The law must take its course.” No titles. No deference. Just “a man in his sixties from Norfolk” released under investigation. Across the Atlantic, though, the picture looks very different. While authorities in the UK move forward, critics say accountability in the U.S. still feels out of reach — even after document dumps, public pressure, and years of unanswered questions surrounding Epstein’s powerful circle.
Andrew Mountbatten-Windsor — brother of Charles III and once one of the most privileged men in Britain — was arrested this week in a stunning twist tied to the fallout from the Jeffrey Epstein files. For the first time in nearly 400 years, a British royal has been taken in for questioning. The message from the Palace? “The law must take its course.” No titles. No deference. Just “a man in his sixties from Norfolk” released under investigation. Across the Atlantic, though, the picture looks very different. While authorities in the UK move forward, critics say accountability in the U.S. still feels out of reach — even after document dumps, public pressure, and years of unanswered questions surrounding Epstein’s powerful circle.

A former prince is arrested in the UK with accountability in question in the US Andrew Mountbatten-Windsor, pictured…

Chaos erupted in the stands — and then something extraordinary happened. Inside the Dennis M. Lynch Arena in Pawtucket, gunfire shattered a youth hockey game as Robert Dorgan opened fire on his own family. But as panic spread and fans scrambled for cover, a handful of bystanders did the unthinkable — they ran toward the shooter. Michael Black thought the shots were popping balloons… until he saw the gun. He told his wife to run — then lunged, jamming his hand into the weapon to stop it from firing. Others piled on. A chokehold. A desperate struggle. Blood on the bleachers. Seconds that felt like forever. Police say those “courageous citizens” likely prevented even more deaths. Now Black is being called a hero — but he says he doesn’t feel like one. What drove ordinary spectators to risk everything in that split second… and how much worse could this have been if they hadn’t?
Chaos erupted in the stands — and then something extraordinary happened. Inside the Dennis M. Lynch Arena in Pawtucket, gunfire shattered a youth hockey game as Robert Dorgan opened fire on his own family. But as panic spread and fans scrambled for cover, a handful of bystanders did the unthinkable — they ran toward the shooter. Michael Black thought the shots were popping balloons… until he saw the gun. He told his wife to run — then lunged, jamming his hand into the weapon to stop it from firing. Others piled on. A chokehold. A desperate struggle. Blood on the bleachers. Seconds that felt like forever. Police say those “courageous citizens” likely prevented even more deaths. Now Black is being called a hero — but he says he doesn’t feel like one. What drove ordinary spectators to risk everything in that split second… and how much worse could this have been if they hadn’t?

When Rhode Island shooter started firing, bystanders jumped into action to end the carnage Moments after Robert Dorgan…

BI00d on the ice. 💔 At the Dennis M. Lynch Arena in Pawtucket, what should have been a routine high school hockey night turned into a nightmare. Authorities say 56-year-old Robert Dorgan opened fire, killing his ex-wife Rhonda Dorgan and their son Aidan before taking his own life — leaving three others critically injured. But this wasn’t random. His daughter, Amanda Wallace-Hubbard, says it was a calculated “vendetta” against their own family. She was in the stands with her young sons when the shots rang out — and says a split-second act of heroism saved their lives. A long trail of family conflict, court battles, and bitter disputes now raises chilling questions about what led to this explosion of violence.
BI00d on the ice. 💔 At the Dennis M. Lynch Arena in Pawtucket, what should have been a routine high school hockey night turned into a nightmare. Authorities say 56-year-old Robert Dorgan opened fire, killing his ex-wife Rhonda Dorgan and their son Aidan before taking his own life — leaving three others critically injured. But this wasn’t random. His daughter, Amanda Wallace-Hubbard, says it was a calculated “vendetta” against their own family. She was in the stands with her young sons when the shots rang out — and says a split-second act of heroism saved their lives. A long trail of family conflict, court battles, and bitter disputes now raises chilling questions about what led to this explosion of violence.

Rhode Island ice rink shooting victims confirmed as shooter’s daughter alleges ‘vendetta’ against family Robert Dorgan’s daughter says…

In Minnesota alone, more than 100 refugees were reportedly arrested in recent weeks before a federal judge stepped in to halt detentions and order releases. A broader court fight is looming — one that could reshape how refugees are treated nationwide. With refugee admissions already slashed and new reviews underway, thousands could be affected. They came to the U.S. legally, fleeing persecution. Now many are asking: after surviving everything else… are they about to face detention here?
In Minnesota alone, more than 100 refugees were reportedly arrested in recent weeks before a federal judge stepped in to halt detentions and order releases. A broader court fight is looming — one that could reshape how refugees are treated nationwide. With refugee admissions already slashed and new reviews underway, thousands could be affected. They came to the U.S. legally, fleeing persecution. Now many are asking: after surviving everything else… are they about to face detention here?

Refugees Without Green Cards Subject to Arrest Under New Policy Image A federal immigration agent in Minneapolis last…

Colbert says network lawyers pressured him not to air it. CBS says that’s not true. Meanwhile, the political backdrop is anything but quiet — from corporate mergers to renewed “equal time” scrutiny from the FCC. And here’s the twist: Talarico’s campaign reportedly raised $2.5 million in the fallout. A segment that never aired on television just became one of the most-watched political interviews online. So what was said that sparked 85 million views — and a network standoff?
Colbert says network lawyers pressured him not to air it. CBS says that’s not true. Meanwhile, the political backdrop is anything but quiet — from corporate mergers to renewed “equal time” scrutiny from the FCC. And here’s the twist: Talarico’s campaign reportedly raised $2.5 million in the fallout. A segment that never aired on television just became one of the most-watched political interviews online. So what was said that sparked 85 million views — and a network standoff?

After Colbert-CBS Rift, Interview With Texas Senate Candidate James Talarico Draws 85M Views Across YouTube & Social  …